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Principal Investigator
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Gerald Shadel

Professor

Staff Scientists
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Zheng Hu

Staff Scientist

My research interest focuses on innovative and unbiased systems biology approaches, such as genomic, epigenomic and epi-transcriptomic analysis, in order to identify the novel regulators and pathways involved in mitochondrial stress signaling and aging in yeast, mammalian and human cells.
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Uri Manor

Staff Scientist

As Director of the Advanced Biophotonics Core Facility at the Salk Institute, Uri Manor’s primary focus is the integration and application of optical and charged particle detection technologies to study problems of critical biological significance. Manor’s current research focuses on developing novel artificial intelligence approaches to increase the resolution, sensitivity and speed of the next generation of microscopes, as well as designing nanoprobes for high spatiotemporal resolution imaging of subcellular dynamics. His main biological interests are mitochondria, hearing loss, neurodegeneration and synaptic plasticity.

Prior to joining Salk, Manor did his PhD thesis research work with Bechara Kachar (NIH), and his postdoctoral training with Jennifer Lippincott-Schwartz (NIH and Janelia Farms) using advanced quantitative imaging approaches, such as superresolution and live cell imaging, automated analysis and segmentation of microscopy data, and computational modeling of biophysical and biochemical dynamics in the cell. By the time Manor completed his postdoctoral training, he had published 17 peer-reviewed publications, all of which relied on his imaging or image analysis skills.

Post-Docs
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Ya-Lan Chang

Post-Doc

I studied cell cycle regulation in graduate school and identified a novel yeast G1/S cyclin-dependent kinase inhibitor. In the Shadel lab, I am studying how mtDNA dynamics and stability are involved in aging using the yeast, Saccharomyces cerevisiae, model system.
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Kailash Chandra Mangalhara

POST-DOC

I received my Ph.D. from Jawaharlal Nehru University, India with a focus on understanding the role of microRNAs in cancer. In the Shadel Lab, I am working on mitochondria-to-nucleus signaling pathways and the role of mitochondrial metabolism in tumor growth, immunogenicity and immunotherapy responses.
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Laura Newman

Post-Doc

I earned my PhD in Rick Kahn’s lab at Emory University, where I studied a small, regulatory GTPase and its functions in mitochondria and mitochondrial dynamics. I joined the Shadel lab so that I could continue studying mitochondria, and I am currently interested in the role of mitochondria in innate immune signaling.
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Ulas Ozkurede

POST-DOC

I majored in electrical and electronics engineering, and received a master’s degree in molecular biology and genetics at Bogaizici University, Istanbul. For my PhD training, I joined the Miller Lab at the University of Michigan, where I studied long-lived mice to assess the role of mitochondrial maintenance on delaying detrimental consequences of aging. We found that long-lived mice had an improved capacity to respond to mitochondrial stress in vivo, and were able to maintain mitochondrial function after stress exposure at the cellular level. At Salk, with Dr. Shadel, we are investigating the long-term protective effects of transient mitochondrial disturbance, and the mechanisms underlying this adaptive response.
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Nimesha Tadepalle

POST-DOC

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Cara Schiavon

Post-doc

I earned my PhD at Emory University in Rick Kahn’s lab where I studied the role of a small GTPase and its GAP in regulating mitochondrial dynamics. I’m currently studying the role of altered mitochondrial and other organellar dynamics/trafficking in Charot-Marie-Tooth disease.
Graduate Students
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Rachael Schwartz

Graduate Student

Cellular senescence is a defense mechanism against cancer in which damaged cells in the body enter replicative arrest and assume a pro-inflammatory phenotype.  These cells accumulate in our bodies with age, and the chronic inflammation they produce can have adverse effects, including causing stem cell dysfunction and, perversely, promoting cancer.  My work involves identifying senescent cells and determining how they can be eliminated from various types of tissues in the body, while leaving healthy cells untouched.  I am focusing on the ways in which changes in mitochondria that occur as we age can lead to cellular senescence.
Lab Technician
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Gladys Rojas

Lab Technician I

Exchange Students
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Alva Sainz

Yale PhD Student

Aging is associated with chronic inflammation that contributes to the development and progression of age-related pathologies. Mitochondrial DNA (mtDNA) has recently been identified as a pathogenic signal that is able to activate several pro-inflammatory signaling pathways. My work involves investigating the contribution of mtDNA signaling to the aging process and understanding how this signaling is regulated.
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Zheng Wu

Yale PhD Student

My research interest focuses on the cross-talk between mitochondria and the nucleus and how mitochondrial DNA stress-associated inflammation contributes to certain human diseases.
Lab Coordinator
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Kym Miller

Lab Coordinator